Glioblastoma multiforme (GBM), also called glioblastoma, is a fast growing glioma that develops from star-shaped glial cells (astrocytes) that support nerve cells. GBM is classified as a grade IV astrocytoma. These are the most invasive type of glial tumors, rapidly growing, and commonly spread to nearby brain tissue. They may be composed of several different kinds of cells (i.e., astrocytes, oligodendrocytes). Sometimes they evolve from a low-grade astrocytoma or an oligodendroglioma. In adults, GBM occurs most often in the cerebral hemispheres, especially in the frontal and temporal lobes of the brain. GBM is a devastating brain cancer that typically results in death in the first 15 months after diagnosis.

GBMs are biologically aggressive tumors that present unique treatment challenges due to the following characteristics: 1) Localization of tumors in the brain; 2) Inherent resistance of these lesions to conventional therapy; 3) Limited capacity of the brain to repair itself; 4) Migration of malignant cells into adjacent brain tissue; 5) The variably disrupted tumor blood supply which inhibits drug delivery; 6) Tumor capillary leakage, resulting in peritumoral edema and intracranial hypertension; 7) A limited response to therapy; and 8) The neurotoxicity of treatments directed at gliomas.

Glioblastoma Multiforme Overview

  • Prevalence and Incidence

  • Symptoms

  • Treatment Options

  • Diagnosis


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