Cushing's syndrome is a disorder caused by an excessive production of cortisol. It can also be caused by excessive use of cortisol or other similar steroid (glucocorticoid) hormones. When too much cortisol is produced in the adrenal glands, or an excess amount is taken as a treatment for other diseases, this affects all of the tissues and organs in the body. These effects together are known as Cushing's syndrome.

Cortisol is a normal hormone produced in the outer portion of the adrenal glands. When functioning normally, cortisol helps the body respond to stress and change. It mobilizes nutrients, modifies the body's response to inflammation, stimulates the liver to raise blood sugar, and helps control the amount of water in the body. Cortisol production is regulated by the adrenocorticotrophic hormone (ACTH), produced in the pituitary gland. Spontaneous overproduction of cortisol in the adrenals is divided into two groups – those attributed to an excess of ACTH and those that are independent of ACTH.

Cushing’s Syndrome/Disease Overview

  • Incidence and Prevalence

  • Familial Cushing's syndrome

  • Risk factors

  • Ectopic ACTH Syndrome

  • Adrenal Tumors

  • Underlying Causes

  • Diagnosis

  • Treatment of Cushing’s disease

  • Treatment of Cushing's syndrome


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